Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Atrial fibrillation (AF) and heart failure (HF) contribute to about 45% of all cardiovascular
disease (CVD) deaths in the USA and around the globe. Due to the complex nature …

Obesity-related heart failure with preserved ejection fraction (HFpEF) has become a well-
recognized HFpEF subphenotype. Targeting the unfavorable cardiometabolic profile may …

BACKGROUND: The p. Arg14del variant of the PLN (phospholamban) gene causes
cardiomyopathy, leading to severe heart failure. Calcium handling defects and perinuclear …

Genetic cardiomyopathies are disorders of the cardiac muscle, most often explained by
pathogenic mutations in genes encoding sarcomere, cytoskeleton, or ion channel proteins …

The phospholamban (PLN) p. Arg14del mutation causes dilated cardiomyopathy, with the
molecular disease mechanisms incompletely understood. Patient dermal fibroblasts were …

Background Heart failure (HF) is the leading cause of morbidity and mortality worldwide, and
there is an urgent need for more global studies and data mining approaches to uncover its …

Arrhythmogenic cardiomyopathy affects significant number of patients worldwide and is
characterized by life-threatening ventricular arrhythmias and sudden cardiac death …

Background: The p.(Arg14del) pathogenic variant (R14del) of the PLN (phospholamban)
gene is a prevalent cause of cardiomyopathy with heart failure. The exact underlying …

Phospholamban (PLN), a key modulator of Ca2+-homeostasis, inhibits sarcoplasmic
reticulum (SR) calcium-ATPase (SERCA2a) and regulates cardiac contractility. The human …