Hypoxia imaging and adaptive radiotherapy: a state-of-the-art approach in the management of glioma

M Gérard, A Corroyer-Dulmont, P Lesueur… - Frontiers in …, 2019 - frontiersin.org
Severe hypoxia [oxygen partial pressure (pO2) below 5–10 mmHg] is more frequent in
glioblastoma multiforme (GBM) compared to lower-grade gliomas. Seminal studies in the …

Early Stage In Vitro Bioprofiling of Potential Low-Molecular-Weight Organoboron Compounds for Boron Neutron Capture Therapy (BNCT)—Proposal for a Guide

ZJ Leśnikowski, F Ekholm, NS Hosmane, M Kellert… - Cells, 2024 - mdpi.com
Given the renewed interest in boron neutron capture therapy (BNCT) and the intensified
search for improved boron carriers, as well as the difficulties of coherently comparing the …

Thermal neutron detection and track recognition method in reference and out-of-field radiotherapy FLASH electron fields using Timepix3 detectors

C Oancea, J Solc, A Bourgouin, C Granja… - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. This work presents a method for enhanced detection, imaging, and measurement
of the thermal neutron flux. Approach. Measurements were performed in a water tank, while …

First independent validation of the proton-boron capture therapy concept

A Jelínek Michaelidesová, P Kundrát, O Zahradníček… - Scientific Reports, 2024 - nature.com
Boron has been suggested to enhance the biological effectiveness of proton beams in the
Bragg peak region via the p+ 11B→ 3α nuclear capture reaction. However, a number of …

Significance of the proton energy loss mechanism to gold nanoparticles in proton therapy: a Geant4 simulation

F Tabbakh - Scientific Reports, 2024 - nature.com
The biological effectiveness in proton therapy is only slightly greater than of the treatment by
X-ray and hence, many researches have suggested the use of gold nanoparticles for …

Increased cell killing effect in neutron capture enhanced proton beam therapy

S Shiba, T Shimo, M Yamanaka, T Yagihashi… - Scientific Reports, 2024 - nature.com
Thermal neutrons generated in the body during proton beam therapy (PBT) can be used to
cause boron neutron capture reactions and have recently been proposed as neutron …

Mapping the relative biological effectiveness of proton, helium and carbon ions with high-throughput techniques

L Bronk, F Guan, D Patel, D Ma, B Kroger, X Wang… - Cancers, 2020 - mdpi.com
Simple Summary Although particle therapy using protons and heavier ions has many
inherent advantages when compared to x-rays for cancer treatment, numerous unknowns …

BeNEdiCTE (Boron Neutron Capture): a versatile gamma-ray detection module for boron neutron capture therapy

A Caracciolo, L Buonanno, D Di Vita… - … on Radiation and …, 2022 - ieeexplore.ieee.org
We present a gamma-ray detection module for quantifying the boron neutron capture events
that occur in the boron neutron capture therapy (BNCT) and neutron capture enhanced …

Detection and discrimination of neutron capture events for NCEPT dose quantification

A Chacon, M Kielly, H Rutherford, DR Franklin… - Scientific reports, 2022 - nature.com
Abstract Neutron Capture Enhanced Particle Therapy (NCEPT) boosts the effectiveness of
particle therapy by capturing thermal neutrons produced by beam-target nuclear interactions …

Investigation of tissue equivalence of phantom biomaterials in 4He heavy ion therapy

F Ekinci - Radiation Effects and Defects in Solids, 2023 - Taylor & Francis
The increase in heavy ion therapy centers worldwide has triggered the search for new ion
types. It has been seen that there is an urgent need for the application of robust biophysical …