BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

Approximately 7% of men suffer from fertility problems, the etiology of which are ascribable
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …

Non-persistent endocrine-disrupting chemicals (EDCs), including phthalates and phenols,
are ubiquitous in both the environment and human body. A growing body of epidemiologic …

It is well established that the maternal diet during the periconceptional period affects the
progeny's health. A growing body of evidence suggests that the paternal diet also influences …

Similar to environmental factors, EDCs (endocrine-disrupting chemicals) can influence gene
expression without modifying the DNA sequence. It is commonly accepted that the …

Currently, most men with infertility cannot be given an aetiology, which reflects a lack of
knowledge around gamete production and how it is affected by genetics and the …

Male fertility has been declining worldwide especially in countries with high levels of
endocrine disrupting chemicals (EDCs). Per-and polyfluorinated alkyl Substances (PFAS) …

Background Conflicting results regarding alterations to sperm DNA methylation in cases of
spermatogenesis defects, male infertility and poor developmental outcomes have been …

STUDY QUESTION Is sperm epigenetic aging (SEA) associated with probability of
pregnancy among couples in the general population? SUMMARY ANSWER We observed a …