The contributors to this statement were selected to ensure expertise in all the disciplines
relevant to post–cardiac arrest care. In an attempt to make this document universally …

A single family of proteases, the caspases, has long been considered the pivotal
executioner of all programmed cell death. However, recent findings of evolutionarily …

AIM OF THE REVIEW: To review the epidemiology, pathophysiology, treatment and
prognostication in relation to the post-cardiac arrest syndrome. METHODS: Relevant articles …

The adult brain is extremely vulnerable to various insults. The recent discovery of neural
progenitors in adult mammals, however, raises the possibility of repairing damaged tissue …

Matrix metalloproteinases (MMPs) are a gene family of neutral proteases that are important
in normal development, wound healing, and a wide variety of pathological processes …

Current knowledge regarding the pathophysiology of cerebral ischemia and brain trauma
indicates that similar mechanisms contribute to loss of cellular integrity and tissue …

Acute post-asphyxial encephalopathy occurring around the time of birth remains a major
cause of death and disability. The recent seminal insight that allows active neuroprotective …

Connections between neurons are affected within 3 min of stroke onset by massive ischemic
depolarization and then delayed cell death. Some connections can recover with prompt …

Apoptosis or programmed cell death has been reported after CNS trauma. However, the
significance of this mechanism in the pathophysiology of spinal cord injury, in particular at …

Hypoxia is a critical factor for cell death or survival in ischemic stroke, but the pathological
consequences of combined ischemia-hypoxia are not fully understood. Here we examine …