Thyrotropin (TSH)-Releasing Hormone Receptor: Interaction with TSH and Autoantibodies* |
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This paper provides the reader with an overview of our current knowledge of hypothalamic‐
pituitary‐thyroid feedback from a cybernetic standpoint. Over the past decades we have …

Endogenous self-reactive autoantibodies (AAs) recognize a range of G-protein-coupled
receptors (GPCRs). They are frequently associated with cardiovascular, neurological, and …

Autoantibodies (Ab) against the thyroid-stimulating hormone receptor (TSHR) are frequently
found in autoimmune thyroid disease (AITD). Autoantibodies to the TSHR (anti-TSHR-Ab) …

Objective Patients who appear to have both stimulating and blocking TSHR autoantibodies
in their sera have been described, but the two activities have not been separated and …

I. Introduction GRAVES'DISEASE is an autoimmune disorder characterized by the presence
of stimulatory anti-TSH receptor antibodies which are thought to act via the TSH receptor to …

Publisher Summary This chapter discusses the current perceptions of the role of the
thyrotropin receptors (TSHR) in disease states. It describes the epitopes of autoantibodies …

Context Bioassays provide information on the functionality of thyrotropin receptor antibodies
(TSH-R-Ab) and thus may offer more clinical utility than binding assays. Objective In this …

The thyrotropin receptor, also known as the thyroid-stimulating hormone receptor (TSHR), is
the primary antigen of Graves disease. Stimulating TSHR antibodies are the cause of thyroid …

The availability of human monoclonal antibodies (MAbs) to the TSHR has enabled major
advances in our understanding of how TSHR autoantibodies interact with the receptor …