The T arget of R apamycin (TOR or mTOR) is a serine/threonine kinase that regulates
growth, development, and behaviors by modulating protein synthesis, autophagy, and …

Over the last decade, the development and prevalence of obesity have posed a serious
public health risk, which has prompted studies on the regulation of adiposity. With the ease …

Chromatin modification and higher-order chromosome structure play key roles in gene
regulation, but their functional interplay in controlling gene expression is elusive. We have …

Gene expression changes during aging are partly conserved across species, and suggest
that oxidative stress, inflammation and proteotoxicity result from mitochondrial malfunction …

Animals integrate external cues with information about internal conditions such as metabolic
state to execute the appropriate behavioral and developmental decisions. Information about …

In Caenorhabditis elegans, the dosage compensation complex (DCC) specifically binds to
and represses transcription from both X chromosomes in hermaphrodites. The DCC is …

Both hedgehog (Hh) and target of rapamycin complex 2 (TORC2) are central, evolutionarily
conserved signaling pathways that regulate development and metabolism. In C. elegans …

TORC1 (target of rapamycin complex 1) plays a central role in regulating growth,
development, and behavior in response to nutrient cues. We previously showed that leucine …

Lifespan regulation by mitochondrial proteins has been well described, however, the
mechanism of this regulation is not fully understood. Amongst the mitochondrial proteins …

Objective Organisms and cellular viability are of paramount importance to living creatures.
Disruption of the balance between cell survival and apoptosis results in compromised …