Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, being
widespread in nature and present in a broad variety of pharmacologically active …

In recent decades, transient and highly reactive ortho-quinodimethanes (o-QDMs), ortho-
quinone methides (o-QMs) and aza-ortho-quinone methides (aza-o-QMs) have attracted …

Developments in synthetic chemistry are increasingly driven by improvements in the
selectivity and sustainability of transformations. Bifunctional reagents, either as dual …

N‐Heterocyclic carbene (NHC) organocatalysis has been developed as an important
approach in modern organic synthesis. Versatile activation modes within NHC …

As a consequence of their propensity towards aromatization, quinone methides (QMs) and
indole imine methides (IIMs) are versatile intermediates in organic synthesis. Although QMs …

First reported less than a decade ago, the α, β-unsaturated acyl azolium has emerged as a
central reactive intermediate for reaction discovery using N-heterocyclic carbene catalysis …

Catalytic, stereoselective N-heterocyclic carbene-catalyzed reactions facilitate efficient
construction of many different heterocyclic compounds, such as the enantioenriched 5 …

This review highlights a number of additives that can be used to make asymmetric reactions
perfect. Without changing other reaction conditions, simply adding additives can lead to …

N-heterocyclic carbene-catalyzed enantioselective kinetic resolutions, dynamic kinetic
resolutions, and desymmetrization reactions are systematically reviewed. The content is …

Quinone methides (QMs) are highly reactive compounds that have been defined as “elusive”
intermediates, or even as a “synthetic enigma” in organic chemistry. Indeed, there were just …