Cell migration is essential for physiological processes as diverse as development, immune
defence and wound healing. It is also a hallmark of cancer malignancy. Thousands of …

Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Precisely controlled cell deformations are key to cell migration, division and tissue
morphogenesis, and have been implicated in cell differentiation during development, as well …

Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

Summary 3D amoeboid cell migration is central to many developmental and disease-related
processes such as cancer metastasis. Here, we identify a unique prototypic amoeboid cell …

Cell migration is central to a multitude of physiological processes, including embryonic
development, immune surveillance, and wound healing, and deregulated migration is key to …

Cell migration underlies tissue formation, maintenance, and regeneration as well as
pathological conditions such as cancer invasion. Structural and molecular determinants of …

During mitosis, adherent animal cells undergo a drastic shape change, from essentially flat
to round,,. Mitotic cell rounding is thought to facilitate organization within the mitotic cell and …

Blebs are cellular protrusions that have been shown to be instrumental for cell migration in
development and disease. Bleb expansion is driven by hydrostatic pressure generated in …