The recent application of 3D-QSAR and docking studies to novel HIV-protease inhibitor drug discovery

FA Olotu, C Agoni, O Soremekun… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction Despite the availability of FDA approved inhibitors of HIV protease, numerous
efforts are still ongoing to achieve 'near-perfect'drugs devoid of characteristic adverse side …

Prevalence of acquired and transmitted HIV drug resistance in Iran: a systematic review and meta-analysis

H Mirzaei, S Eybpoosh, F Mehrabi, MR Shojaei… - BMC Infectious …, 2024 - Springer
Background There is no systematic review on the prevalence of HIV drug resistance
(HIVDR) in Iran. We aimed to estimate the prevalence of HIVDR among people living with …

Naturally occurring mutations in HIV-1 protease gene among people living with HIV

Z Hasanshahi, A Hashempour, J Moayedi… - Acta Medica …, 2023 - acta.tums.ac.ir
The emergence of resistance to antiretroviral drugs is the main problem in their long-term
efficacy and by considering the wide use of protease inhibitors (PIs), monitoring drug …

A survey of resistance mutations to reverse transcriptase inhibitors (RTIs) among HIV-1 patients in northeast of Iran

Z Mazaheri, S Tahaghoghi-Hajghorbani… - Molecular Biology …, 2024 - journals.shirazu.ac.ir
The use of a combination of three-drug regimen has improved HIV-1 infected patients' life
span and quality; however the emergence of drug-resistant strains remains a main problem …

Human Immunodeficiency Virus-1 Drug Resistance Mutations in Iranian Treatment-experienced Individuals

F Bokharaei-Salim, K Khanaliha… - Current HIV …, 2024 - benthamdirect.com
Background Human immunodeficiency virus-1 infection still remains a global health threat.
While antiretroviral therapy is the primary treatment option, concerns about the emergence …