Cells are continuously exposed to a variety of environmental stresses and have to decide 'to
be or not to be'depending on the types and strength of stress. Among the many signaling …

The c-Jun amino-terminal kinase (JNK) group of MAP kinases has been identified in
mammals and insects. JNK is activated by exposure of cells to cytokines or environmental …

Single endothelial cells (EC) seeded in suspension culture rapidly undergo apoptosis.
Addition of survival factors, such as VEGF and FGF-2, does not prevent apoptosis of …

Identification of the key roles of protein kinases in cancer has led to extensive efforts to
develop kinase inhibitors for the treatment of a wide range of cancers, and more than 30 …

Nitric oxide (NO) has emerged as an important endogenous inhibitor of apoptosis, and here
we report that NO prevents hepatocyte apoptosis initiated by the removal of growth factors or …

Part of the cellular response to toxins, physical stresses and inflammatory cytokines occurs
by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase …

Apoptosis induced by DNA damage and other stresses can proceed via expression of Fas
ligand (FasL) and ligation of its receptor, Fas (CD95). We report that activation of the two …

Neurons are an unusual type of cell in that they send processes (axons and dendrites) over
great distances. This elaborate morphology, together with their excitability, places neurons …

The essential cellular functions associated with microtubules have led to a wide use of
microtubule-interfering agents in cancer chemotherapy with promising results. Although the …

Hsp72, a major inducible member of the heat shock protein family, can protect cells against
many cellular stresses including heat shock. In our present study, we observed that …