The present review offers an overview of nonclassical (eg, with no pre-or in situ activation of
a carboxylic acid partner) approaches for the construction of amide bonds. The review aims …

The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

The investigation of biological processes by chemical methods, commonly referred to as
chemical biology, often requires chemical access to biologically relevant macromolecules …

The construction of complex protein folds relies on the precise conversion of a linear
polypeptide chain into a compact 3-dimensional structure. The interplay of forces that link …

Peptide C-terminal thioesters are key intermediates in a variety of applications, most notably
the recently developed native chemical ligation methods for the total chemical synthesis of …

Symbiosis is an association between different organisms that leads to a reciprocal
enhancement of their ability to survive. Similar mutually beneficial relationships can operate …

Living cells can process rapidly and simultaneously multiple extracellular input signals
through the complex networks of evolutionary selected biomolecular interactions and …

Self-replication has been demonstrated in synthetic chemical systems based on
oligonucleotides,,,,,,, peptides,,,, and complementary molecules without natural analogues …

Biological self‐assembly is very complex and results in highly functional materials. In effect,
it takes a bottom‐up approach using biomolecular building blocks of precisely defined …

Site-directed mutagenesis is still a very efficient strategy to elaborate improved enzymes.
Recently, advances have been made in developing rational strategies aimed at reshaping …