DNA adducting drugs, including alkylating agents and platinum-containing drugs, are
prominent in cancer chemotherapy. Their mechanisms of action involve direct interaction …

Scaffold-based drug design has become increasingly prominent in the pharmaceutical field
due to the systematic and effective approach through which it facilitates the development of …

Density functional theory with the ωB97X-D exchange–correlation functional together with
implicit as well as explicit solvation is used to describe the reactions of the adenine and …

A reaction pathway by which thiotepa (iV^ V'^ V'-triethylenethiophosphoramide) and tepa
(iV^ V'^ V'-triethylenephosphoramide), its major metabolite in humans, alkylate and …

Cancer research is becoming multidisciplinary. The complex structural and therapeutic
problems require synergistic approaches employing an assortment of biochemical …

High-performance liquid chromatography (HPLC) and thermospray mass spectrometry were
combined for the analysis of DNA adducts formed from the interaction of the anticancer …

By the methods of fast atom bombardment (FAB) mass spectrometry, thin‐layer
chromatography and ultraviolet absorption spectroscopy adducts have been studied which …

This article reviews the results of mass spectrometric investigations of the formation
mechanism and the energy stabilty of the bioclusters DNA and RNA nucleotide pairs, and …

Abstract N, N′, N ″-Triethylenethiophosphoramide ([14C] thiotepa) accumulation by
L1210 cells is a biphasic process. A very rapid initial phase is followed by a much slower …

Because the transport and accumulation of N, N', N''-triethylenethiophosphoramide
(thiotepa) by cells has not been characterized, these processes were investigated with [14C] …