Abstract Endometrial cancer accounts for~ 76,000 deaths among women each year
worldwide. Disease mortality and the increasing number of new diagnoses make …

Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …

Background We have previously developed and confirmed a pragmatic molecular classifier
for endometrial cancers; ProMisE (Proactive Molecular Risk Classifier for Endometrial …

BACKGROUND Classification of endometrial carcinomas (ECs) by morphologic features is
irreproducible and imperfectly reflects tumor biology. The authors developed the Proactive …

Pathogenic somatic missense mutations within the DNA polymerase epsilon (POLE)
exonuclease domain define the important subtype of ultramutated tumours ('POLE …

POLE and POLD1 encode the catalytic and proofreading subunits of DNA polymerase ε and
polymerase δ, and play important roles in DNA replication and proofreading. POLE/POLD1 …

Background: Classification of endometrial carcinomas (ECs) by morphologic features is
inconsistent, and yields limited prognostic and predictive information. A new system for …

BACKGROUND Endometrial hyperplasia (EH) is a uterine pathology representing a
spectrum of morphological endometrial alterations. It is predominantly characterized by an …

Endometrial carcinoma (EC) is classified into a wide range of morphological variants; this list
has expanded over the past decade with the inclusion of mesonephric‐like and …

Although it has long been recognized that the exonucleolytic proofreading activity intrinsic to
the replicative DNA polymerases Pol δ and Pol ε is essential for faithful replication of DNA …