The tumour immune microenvironment is shaped by the crosstalk between cancer cells,
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …

Aberrant adenosine diphosphate-ribose (ADP)-ribosylation of proteins and nucleic acids is
associated with multiple disease processes such as infections and chronic inflammatory …

Macrophages are phagocytic cells with important physiological functions, including the
digestion of cellular debris, foreign substances, and microbes, as well as tissue …

Aims PARP inhibitors (PARPi) are known to exert anti-tumor effects in patients with BRCA-
mutated (BRCAmut) or homologous recombination (HR)-deficient cancer, but recent clinical …

Highlights•Current strategies to map lipids, metabolites, and proteins in tumor
tissues.•Recent biological insights obtained from MSI of tumor samples.•Challenges in …

Background Ischemic stroke is a leading cause of death and long-term disability worldwide.
Studies have suggested that cerebral ischemia induces massive mitochondrial damage …

The emergence of PARP inhibitors as a therapeutic strategy for tumors with high genomic
instability, particularly those harboring BRCA mutations, has advanced cancer treatment …

Background Ovarian cancer (OC) remains one of the most challenging and deadly
malignancies facing women today. While PARP inhibitors (PARPis) have transformed the …

According to international cancer data, breast cancer (BC) is the leading type of cancer in
women. Although significant progress has been made in treating BC, metastasis and drug …

PURPOSE Homologous recombination deficiency (HRD) is highly prevalent in triple-
negative breast cancer (TNBC) and associated with response to PARP inhibition (PARPi) …