Trypanosoma cruzi interacts with the different arms of the innate and adaptive host's immune
response in a very complex and flowery manner. The history of host-parasite co-evolution …

Infection with the protozoan parasite Trypanosoma cruzi, the agent of Chagas disease, is
characterised by a variable clinical course–from symptomless cases to severe chronic …

Innate and adaptive cellular immune recognition is crucial for control of the protozoan
parasite Trypanosoma cruzi. T. cruzi triggers both MyD88-dependent and TRIF-dependent …

The acute phase of Chagas disease lasts 4–8 weeks and is characterized by
microscopically detectable parasitaemia. Symptoms are usually mild with severe acute …

CD8+ T cells have emerged as crucial players in the control of a number of protozoan
pathogens, including Trypanosoma cruzi, the agent of human Chagas disease. The recent …

In Chagas disease, CD8+ T-cells are critical for the control of Trypanosoma cruzi during
acute infection. Conversely, CD8+ T-cell accumulation in the myocardium during chronic …

Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a prototypical
neglected tropical disease. Specific immunity promotes acute phase survival. Nevertheless …

ABSTRACT A heterologous prime-boost strategy using plasmid DNA, followed by replication-
defective recombinant adenovirus 5, is being proposed as a powerful way to elicit CD4+ and …

Chagas disease, caused by Trypanosoma cruzi, results in an acute febrile illness that
progresses to chronic chagasic cardiomyopathy in 30% of patients. Current treatments have …

In mammals, chronic diseases resulting from infectious agents have been associated with
functional T cell response deficiency, a high frequency of terminally differentiated T cells, the …