Autoimmune cytopenias, particularly autoimmune hemolytic anemia (AIHA) and immune
thrombocytopenia (ITP), complicate up to 25% of chronic lymphocytic leukemia (CLL) cases …

Natural killer cell stimulatory factor (NKSF), or interleukin 12 (IL-12), is a 70-kD
heterodimeric cytokine composed of two covalently linked chains, p40 and p35. NKSF/IL-12 …

Infection with human immunodeficiency virus-type 1 (HIV-1) depletes T cells expressing
CD4 and B cells expressing immunoglobulin (Ig) VH3 gene products. A subpopulation of …

For several decades, B-cell interactions with antigens were thought to occur only through a
clonal activation mechanism, in which the bypervariable regions of the immunoglobulin …

Although idiopathic thrombocytopenic purpura (ITP) is the most common autoimmune
hematologic disorder, little is known about the associated autoantibodies on a molecular …

In a recent study we reported that CD27 is expressed on a subpopulation of human B
lymphocytes and presented circumstantial phenotypic evidence that CD27 expression may …

Fibromodulin is an extracellular matrix protein normally produced by collagen-rich tissues;
the fibromodulin gene has been found to be the most overexpressed gene in B-cell chronic …

Proteins of the basic helix-loop-helix (bHLH) family are required for a number of different
developmental pathways, including neurogenesis, lymphopoiesis, myogenesis, and sex …

SLE is a multisystem autoimmune disease characterized by multiple immunological
abnormalities including production of autoantibodies. While the etiology of SLE is largely …

Determination of the frequency of specific B lymphocytes has important implications for
investigation of the immune response to different antigens and pathogens …