The sarcomere is the smallest functional unit of muscle contraction. It is delineated by a
protein-rich structure known as the Z-disk, alternating with M-bands. The Z-disk anchors the …

The Z-disc acts as a protein-rich structure to tether thin filament in the contractile units, the
sarcomeres, of striated muscle cells. Proteins found in the Z-disc are integral for maintaining …

Background Mutations in filamin-C (FLNC) are involved in the pathogenesis of
arrhythmogenic cardiomyopathy (ACM) and dilated cardiomyopathy (DCM), and have been …

Rationale: Dominant heterozygous variants in filamin C (FLNC) cause diverse
cardiomyopathies, although the underlying molecular mechanisms remain poorly …

Cardiomyopathy affects approximately 1 in 500 adults and is the leading cause of death.
Familial cases are common, and mutations in many genes are involved in cardiomyopathy …

Inflammation promotes adverse ventricular remodeling, a common antecedent of heart
failure. Here, we set out to determine how inflammatory cells affect cardiomyocytes in the …

Phenotypic plasticity, or adaptability, of a cell determines its ability to survive and function
within changing cellular environments. Changes in the mechanical environment, ranging …

Restrictive cardiomyopathy is a rare cardiac disease causing severe diastolic dysfunction,
ventricular stiffness and dilated atria. In consequence, it induces heart failure often with …

Restrictive cardiomyopathy (RCM) is defined as increased myocardial stiffness and impaired
diastolic relaxation leading to elevated ventricular filling pressures. Human variants in …

Cardiomyocytes, the cells generating contractile force in the heart, are connected to each
other through a highly specialised structure, the intercalated disc (ID), which ensures force …