In the past few years macromolecular crystallography has become a standard technique
used by many pharmaceutical and biotechnology companies. This methodology offers …

The therapy of chronic inflammatory diseases like rheumatoid arthritis (RA) and
inflammatory bowel disease (IBD) has recently been enriched by the successful launch of …

2009-02-04 Assigned to ARRAY BIOPHARMA, INC. reassignment ARRAY BIOPHARMA,
INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …

The quinazolinone and pyridol-pyrimidine classes of p38 MAP kinase inhibitors have a
previously unseen degree of specificity for p38 over other MAP kinases. Comparison of the …

Development for a class of potent 3, 4-dihydropyrido (3, 2-d) pyrimidone inhibitors of p38a
MAP kinase is described. Modification of N-1 aryl and C-6 arylsulfide in 3, 4-dihydropyrido …

The recent successful introduction of the anti‐cytokine biologicals Etanercept, Infliximab,
Adalimumab, and Anakinra has stimulated the search for anti‐cytokine small‐molecules. A …

This invention relates to inhibitors of p38, and methods for producing these inhibitors. The
invention also provides pharmaceutical compositions comprising the inhibitors of the …

Background The circadian clock is the basis for biological time keeping in eukaryotic
organisms. The clock mechanism relies on biochemical signaling pathways to detect …

At the time of writing, there are seven marketed kinase inhibitor drugs. The first kinase
inhibitor, imatinib mesilate (Gleevec®, Novartis), came to market in 2001, an inhibitor of the …

Microwave irradiation promotes the rapid and efficient reaction of a thiophenol and aryl or
heteroaryl halide using a copper or palladium catalyst and a range of ligands, depending …