Ion channels and transporters mediate the transport of charged ions across hydrophobic
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Dendritic cells play a key role in processing and presenting antigens to naïve T cells to
prime adaptive immunity. Circadian rhythms are known to regulate many aspects of …

An immunosuppressive tumour microenvironment strongly influences response rates in
patients receiving immune checkpoint blockade-based cancer immunotherapies, such as …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Abstract Ca2+-activated, non-selective (CAN) ion channels sense increases of the
intracellular Ca2+ concentration, producing a flux of Na+ and/or K+ ions that depolarizes the …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

MicroRNAs (miRNAs) are involved in the regulation of immunity, including the lymphocyte
development and differentiation, and inflammatory cytokine production. Dendritic cells (DCs) …

Store‐operated Ca2+ entry (SOCE) is a mechanism used by many cells types including
lymphocytes and other immune cells to increase intracellular Ca2+ concentrations to initiate …

A complex network of many interacting mechanisms orchestrates immune and inflammatory
responses. Among these, the cation channels of the transient receptor potential (TRP) family …