Ion channel degeneracy, variability, and covariation in neuron and circuit resilience
JM Goaillard, E Marder - Annual review of neuroscience, 2021 - annualreviews.org
The large number of ion channels found in all nervous systems poses fundamental
questions concerning how the characteristic intrinsic properties of single neurons are …
questions concerning how the characteristic intrinsic properties of single neurons are …
[HTML][HTML] Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair
Due to its complex and multifaceted nature, developing effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …
The microcircuits of striatum in silico
JJJ Hjorth, A Kozlov, I Carannante… - Proceedings of the …, 2020 - National Acad Sciences
The basal ganglia play an important role in decision making and selection of action primarily
based on input from cortex, thalamus, and the dopamine system. Their main input structure …
based on input from cortex, thalamus, and the dopamine system. Their main input structure …
[HTML][HTML] Introducing the Dendrify framework for incorporating dendrites to spiking neural networks
Computational modeling has been indispensable for understanding how subcellular
neuronal features influence circuit processing. However, the role of dendritic computations …
neuronal features influence circuit processing. However, the role of dendritic computations …
[HTML][HTML] Visualization of currents in neural models with similar behavior and different conductance densities
Conductance-based models of neural activity produce large amounts of data that can be
hard to visualize and interpret. We introduce visualization methods to display the dynamics …
hard to visualize and interpret. We introduce visualization methods to display the dynamics …
[HTML][HTML] Hippocampome. org 2.0 is a knowledge base enabling data-driven spiking neural network simulations of rodent hippocampal circuits
Hippocampome. org is a mature open-access knowledge base of the rodent hippocampal
formation focusing on neuron types and their properties. Previously, Hippocampome. org v1 …
formation focusing on neuron types and their properties. Previously, Hippocampome. org v1 …
Data‐driven integration of hippocampal CA1 synaptic physiology in silico
The anatomy and physiology of monosynaptic connections in rodent hippocampal CA1 have
been extensively studied in recent decades. Yet, the resulting knowledge remains disparate …
been extensively studied in recent decades. Yet, the resulting knowledge remains disparate …
[HTML][HTML] Mearec: a fast and customizable testbench simulator for ground-truth extracellular spiking activity
AP Buccino, GT Einevoll - Neuroinformatics, 2021 - Springer
When recording neural activity from extracellular electrodes, both in vivo and in vitro, spike
sorting is a required and very important processing step that allows for identification of single …
sorting is a required and very important processing step that allows for identification of single …
[HTML][HTML] Circadian modulation of neurons and astrocytes controls synaptic plasticity in hippocampal area CA1
JP McCauley, MA Petroccione, LY D'Brant, GC Todd… - Cell reports, 2020 - cell.com
Most animal species operate according to a 24-h period set by the suprachiasmatic nucleus
(SCN) of the hypothalamus. The rhythmic activity of the SCN modulates hippocampal …
(SCN) of the hypothalamus. The rhythmic activity of the SCN modulates hippocampal …
Degeneracy in hippocampal physiology and plasticity
RK Rathour, R Narayanan - Hippocampus, 2019 - Wiley Online Library
Degeneracy, defined as the ability of structurally disparate elements to perform analogous
function, has largely been assessed from the perspective of maintaining robustness of …
function, has largely been assessed from the perspective of maintaining robustness of …