Immune reconstitution inflammatory syndrome (IRIS) presents as an exaggerated immune
reaction that occurs during dysregulated immune restoration in immunocompromised …

The ability to overcome metabolic stress is a major determinant of outcomes during
infections. Pathogens face nutrient and oxygen deprivation in host niches and during their …

Bacterial persisters, a subpopulation of genetically susceptible cells that are normally
dormant and tolerant to bactericides, have been studied extensively because of their clinical …

Fungal infections are a global threat, but treatments are limited due to a paucity in antifungal
drug targets and the emergence of drug-resistant fungi such as Candida auris. Metabolic …

To understand the genetic basis and selective forces acting on longevity, it is useful to
examine lifespan variation among closely related species, or ecologically diverse isolates of …

Background yqiC is required for colonizing the Salmonella enterica serovar Typhimurium (S.
Typhimurium) in human cells; however, how yqiC regulates nontyphoidal Salmonella (NTS) …

Cryptococcus neoformans (Cn) is an opportunistic yeast that causes meningoencephalitis in
immunocompromised individuals. Calorie restriction (CR) prolongs Cn replicative lifespan …

Cryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-
threatening meningoencephalitis. During the infection, the microbial population is …

Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent
kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 …

Dormancy is an adaptation in which cells reduce their metabolism, transcription, and
translation to stay alive under stressful conditions, preserving the capacity to reactivate once …