The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness
cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism …

Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …

The circadian clock and feeding rhythms are both important regulators of rhythmic gene
expression in the liver. To further dissect the respective contributions of feeding and the …

The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …

The mammalian liver is a central hub for systemic metabolic homeostasis. Liver tissue is
spatially structured, with hepatocytes operating in repeating lobules, and sub-lobule zones …

All biological processes, living organisms, and ecosystems have evolved with the Sun that
confers a 24-hour periodicity to life on Earth. Circadian rhythms arose from evolutionary …

Disrupted circadian activity is associated with many neuropsychiatric disorders. A major
coordinator of circadian biological systems is adrenal glucocorticoid secretion which exhibits …

A substantial body of research now implicates the circadian clock in the regulation of an
array of diverse biological processes including glial function, metabolism, peripheral …

The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of
time for the organism. The synchrony between the daily challenges imposed by the …

Circadian regulation of transcriptional processes has a broad impact on cell metabolism.
Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial …