Regulation of inflammatory cytokines for spinal cord injury repair through local delivery of therapeutic agents

H Ren, X Chen, M Tian, J Zhou, H Ouyang… - Advanced …, 2018 - Wiley Online Library
The balance of inflammation is critical to the repair of spinal cord injury (SCI), which is one of
the most devastating traumas in human beings. Inflammatory cytokines, the direct mediators …

Chaperone proteins in the central nervous system and peripheral nervous system after nerve injury

SS Ousman, A Frederick, EMF Lim - Frontiers in Neuroscience, 2017 - frontiersin.org
Injury to axons of the central nervous system (CNS) and the peripheral nervous system
(PNS) is accompanied by the upregulation and downregulation of numerous molecules that …

Intranasal interferon-beta alleviates anxiety and depressive-like behaviors by modulating microglia polarization in an Alzheimer's disease model

M Farhangian, F Azarafrouz, S Chavoshinezhad… - Neuroscience …, 2023 - Elsevier
Alzheimer's disease (AD) patients frequently experience neuropsychiatric symptoms (NPS),
which are linked to a lower quality of life and a faster rate of disease progression. A growing …

Interferon beta attenuates recognition memory impairment and improves brain glucose uptake in a rat model of Alzheimer's disease: Involvement of mitochondrial …

F Azarafrouz, M Farhangian, S Chavoshinezhad… - Neuropeptides, 2022 - Elsevier
Interferon beta (IFNβ) is a cytokine with anti-apoptotic and anti-inflammatory properties, and
its beneficial effects on Alzheimer's disease (AD) have been recently shown. The alterations …

Interferon beta ameliorates cognitive dysfunction in a rat model of Alzheimer's disease: Modulation of hippocampal neurogenesis and apoptosis as underlying …

S Chavoshinezhad, HM Kouchesfahani… - Progress in Neuro …, 2019 - Elsevier
Neuronal apoptosis and impaired hippocampal neurogenesis are major players in
cognitive/memory dysfunctions including Alzheimer's disease (AD). Interferon beta (IFNβ) is …

Recombinant human erythropoietin and interferon-β-1b protect against 3-nitropropionic acid-induced neurotoxicity in rats: possible role of JAK/STAT signaling …

RH Sayed, AH Ghazy, MFE Yammany - Inflammopharmacology, 2022 - Springer
Nitropropionic acid (3-NP) model serves as a beneficial tool to evaluate the effect of novel
treatments for Huntington's disease (HD). The aim of the present study was to demonstrate …

Intranasal interferon beta improves memory and modulates inflammatory responses in a mutant APP-overexpressing rat model of Alzheimer's disease

S Chavoshinezhad, HM Kouchesfahani, MS Salehi… - Brain research …, 2019 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by
progressive cognitive decline. According to the critical role of inflammation in pathogenesis …

The role of interferon beta in neurological diseases and its potential therapeutic relevance

M Farhangian, F Azarafrouz, N Valian… - European Journal of …, 2024 - Elsevier
Interferon beta (IFNβ) is a member of the type-1 interferon family and has various
immunomodulatory functions in neuropathological conditions. Although the level of IFNβ is …

Intranasal interferon-beta as a promising alternative for the treatment of Alzheimer's disease

S Chavoshinezhad, V Safari, E Izadpanah - Medical Hypotheses, 2023 - Elsevier
Deterioration in cognitive abilities, especially memory, is characteristic of Alzheimer's
disease (AD), a type of neurodegenerative disease. AD's pathological lesions include …

[PDF][PDF] Neuroprotective effects of lacosamide in experimental traumatic spinal cord injury in rats

S DEMİRÖZ, K Ur, A Ulucan, A Bengu… - Turkish …, 2019 - avesis.kocaeli.edu.tr
Neuroprotective Effects of Lacosamide in Experimental Traumatic Spinal Cord Injury in Rats
Page 1 718 Ozlem OZ GERGIN Sevki ERDEM Serdar DEMIROZ Koray UR Aykut ULUCAN …