Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …

Copper is an essential trace element required by all living organisms. Excess amounts of
copper, however, results in cellular damage. Disruptions to normal copper homeostasis are …

Wilson disease (WD) is a rare disorder caused by mutations in ATP7B, which leads to the
defective biliary excretion of copper. The subsequent gradual accumulation of copper in …

Copper is an essential trace element that is required for the activity of many enzymes and
cellular processes, including energy homeostasis and neurotransmitter biosynthesis; …

Background: Alzheimer's disease (AD) is the most common cause of dementia and cognitive
decline in the elderly. Although the etiology of AD is unknow, an increase in amyloid …

Hereditary forms of copper toxicosis exist in man and dogs. In man, Wilson's disease is the
best studied disorder of copper overload, resulting from mutations in the gene coding for the …

ATP7B mutations result in Cu storage in the liver and brain in Wilson disease (WD). Atox1
and COMMD1 were found to interact with ATP7B and involved in copper transport in the …

Copper is a trace element indispensable for life, but at the same time it is implicated in
reactive oxygen species formation. Several inherited copper storage diseases are described …

Wilson disease (WD) is caused by defects in ATP7B gene due to impairment of normal
function of the copper transporting P-type ATPase. This study describes a comprehensive …

Meta-analyses show that serum copper non-bound-to-ceruloplasmin (non-Cp-Cu) is higher
in patients with Alzheimer's disease (AD). ATP7B gene variants associate with AD …