Cardiovascular diseases cause more mortality and morbidity worldwide than any other
diseases. Although many intracellular signaling pathways influence cardiac physiology and …

The NO/ONOO-cycle is a primarily local, biochemical vicious cycle mechanism, centered on
elevated peroxynitrite and oxidative stress, but also involving 10 additional elements: NF-κB …

Pathological cardiac hypertrophy is characterized by subcellular remodeling of the
ventricular myocyte with a reduction in the scaffolding protein caveolin-3 (Cav-3), altered Ca …

Nitric oxide regulates BP by binding the reduced heme iron (Fe 2+) in soluble guanylyl
cyclase (sGC) and relaxing vascular smooth muscle cells (SMCs). We previously showed …

The β 1-adrenergic antagonist metoprolol improves cardiac function in animals and patients
with chronic heart failure, isolated mitral regurgitation (MR), and ischemic heart disease …

Heart failure (HF) is a shared manifestation of several cardiovascular pathologies, including
hypertension and myocardial infarction, and a limited repertoire of treatment modalities …

Impaired nitric oxide (NO)–soluble guanylate cyclase (sGC)–cGMP signaling is involved in
the pathogenesis of ischemic heart diseases, yet the impact of long-term sGC activation on …

Objective: Cardiovascular research and regenerative strategies have been significantly
limited by the lack of relevant cell culture models that can recreate complex hemodynamic …

The mitral valve exists in a mechanically demanding environment, with the stress of each
cardiac cycle deforming and shearing the native fibroblasts and endothelial cells. Cells and …

Heart failure (HF) remains a major cause of death and hospitalization worldwide. Despite
medical advances, the prognosis of HF remains poor and new therapeutic approaches are …