Genetically engineered mouse models are commonly preferred for studying the human
disease due to genetic and pathophysiological similarities between mice and humans. In …

The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite
for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular …

Low-protein diets promote metabolic health in rodents and humans, and the benefits of low-
protein diets are recapitulated by specifically reducing dietary levels of the three branched …

Glucose consumption is generally increased in tumor cells to support tumor growth.
Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during …

Spinal cord injury in mammals is thought to trigger scar formation with little regeneration of
axons,,–. Here we show that a crush injury to the spinal cord in neonatal mice leads to scar …

Consumption of fructose has risen markedly in recent decades owing to the use of sucrose
and high-fructose corn syrup in beverages and processed foods, and this has contributed to …

Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the
idea that a molecular clock is necessary for metabolic homeostasis. However, these mice …

Autophagy contributes to the selective degradation of liquid droplets, including the P-
Granule, Ape1-complex and p62/SQSTM1-body, although the molecular mechanisms and …

The hypothalamic arcuate–median eminence complex (Arc-ME) controls energy balance,
fertility and growth through molecularly distinct cell types, many of which remain unknown …

Primary liver cancer represents a major health problem. It comprises hepatocellular
carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), which differ markedly with …