Parkinson's disease (PD) is a movement disorder that is characterized by the progressive
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …

Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …

Mitochondria are highly dynamic organelles which fulfill a plethora of functions. In addition to
their prominent role in energy metabolism, mitochondria are intimately involved in various …

Objective To understand belief in a specific scientific claim by studying the pattern of
citations among papers stating it. Design A complete citation network was constructed from …

BACKGROUND: The genetics and pathophysiology of Alzheimer Disease (AD) and
Parkinson Disease (PD) appears complex. However, mitochondrial dysfunction is a common …

Background Maintaining skeletal muscle mitochondrial content and function is important for
sustained health throughout the lifespan. Exercise stimulates important key stress signals …

Highlights•PINK1 and Parkin are implicated in regulating mitophagy but in vivo evidence is
conflicting.•Results support a complex and subtle process of mitochondrial quality …

Parkinson's disease (PD), the most frequent movement disorder, is caused by the
progressive loss of the dopamine neurons within the substantia nigra pars compacta (SNc) …

Loss-of-function mutations in the genes encoding Parkin and PINK1 are causally linked to
autosomal recessive Parkinson's disease (PD). Parkin, an E3 ubiquitin ligase, and PINK1, a …

Mutations in PARKIN, PTEN-induced kinase 1 (PINK1) and DJ-1 are found in autosomal
recessive forms and some sporadic cases of Parkinson's disease. Recent work on these …