Oxidative stress is implicated as an important molecular mechanism underlying fibrosis in a
variety of organs, including the lungs. However, the causal role of reactive oxygen species …

Mitochondria are energy factories of cells and are important pivots for intracellular
interactions with other organelles. They interact with the endoplasmic reticulum …

Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

More than a billion years ago, bacterial precursors of mitochondria became endosymbionts
in what we call eukaryotic cells today. The true significance of the word “endosymbiont” has …

Inter-organelle signaling plays important roles in many physiological functions. Endoplasmic
reticulum (ER)–mitochondrion signaling affects intramitochondrial calcium (Ca 2+) …

Studying organelles in isolation has been proven to be indispensable for deciphering the
underlying mechanisms of molecular cell biology. However, observing organelles in intact …

In the last decades, the communication between the Endoplasmic reticulum (ER) and
mitochondria has obtained great attention: mitochondria-associated membranes (MAMs) …

Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes
appear to share common mechanisms of neuronal cellular dysfunction, including …

Alzheimer disease (AD) is associated with the accumulation in the brain of extracellular
neuritic plaques composed mainly of β-amyloid (Aβ) and of intracellular neurofibrillary …

Calcium homeostasis is central to all cellular functions and has been studied for decades.
Calcium acts as a critical second messenger for both extracellular and intracellular signaling …