Nanotechnology has begun to play a remarkable role in various fields of science and
technology. In biomedical applications, nanoparticles have opened new horizons, especially …

Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling
metabolites whose versatile modes of action are being increasingly appreciated. These …

Circulating phosphate levels are tightly controlled within a narrow range in mammals. By
using a novel small-molecule inhibitor, we show that the enzymatic activity of inositol …

Insufficient drug release as well as poor drug penetration are major obstacles for effective
nanoparticles (NPs)‐based cancer therapy. Herein, the high aqueous instability of …

Careful selection of photocaging approaches is critical to achieve fast and well synchronized
reaction initiation and perform successful time-resolved structural biology experiments. This …

From the early precipitation-based techniques, introduced more than a century ago, to the
latest development of enzymatic bio-and nano-sensor applications, the analysis of phytic …

New strategies are urgently needed to target MRSA, a major global health problem and the
leading cause of mortality from antibiotic-resistant infections in many countries. Here, we …

Phosphate's central role in most biochemical reactions in a living organism requires
carefully maintained homeostasis. Although phosphate homeostasis in mammals has long …

Technical challenges have to date prevented a complete profiling of the levels of myo-
inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we …

The combinatorial phosphorylation of myo-inositol results in the generation of different
inositol phosphates (InsPs), of which phytic acid (InsP6) is the most abundant species in …