Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …

Patients with cirrhosis are prone to develop acute kidney injury (AKI), a complication
associated with a markedly increased in-hospital morbidity and mortality, along with a risk of …

The mechanisms underlying the remarkable capacity of the liver to regenerate are still not
completely understood. Particularly, the cross-talk between cytokines and cellular …

Background: Sodium and fluid retention in liver disease are classically thought to result from
reduced effective circulating volume and stimulation of the renin-angiotensin-aldosterone …

Introduction Progressive familial intrahepatic cholestasis (PFIC) is a group of disorders
characterized by inappropriate bile formation, causing hepatic accumulation of bile acids …

Modulating bile salt homeostasis has proven a promising treatment strategy in models of
cholestasis and are continuously being further developed. Confirmatory clinical studies are …

Acetaminophen (APAP) is known to cause a breach of the blood–bile barrier in mice that, via
a mechanism called futile bile acid (BA) cycling, increases BA concentrations in hepatocytes …

Next-generation sequencing (NGS) technologies have revolutionized diagnostic
approaches, while discovery of new intracellular signaling pathways show promise in …

Bile acids (BAs) serve as signalling molecules, efficiently regulating their own metabolism
and transport, as well as key aspects of lipid and glucose homeostasis. BAs shape the gut …

The intestinal bile acid carrier ASBT (SLC10A2), the hepatic bile acid carrier NTCP
(SLC10A1), and the steroid sulfate carrier SOAT (SLC10A6), all members of the solute …