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Metformin (MTF) is a widely used oral antidiabetic medication. Regardless the reason, high
doses of MTF cause lactic acidosis as a result of its effects on mitochondrial ATP production …

Introduction Severe metformin overdose can result in life-threatening conditions such as
metabolic acidosis with hyperlactatemia and vasoplegic shock. Current treatment guidelines …

Metformin toxicity is a life-threatening condition with high morbidity and mortality. Toxicity
predominantly occurs in the setting of acute renal dysfunction, as the drug is solely …

Abstract GdVO4: Eu3+ nanoparticles (OVNPs) have previously been shown to exhibit anti-
aging effects in old rats. The accelerated aging model (overnutrition in early postnatal …

Background: Metformin is a biguanide hyperglycemic agent used to manage non–insulin-
dependent diabetes mellitus. Adverse reactions include mainly mild gastrointestinal adverse …

Introduction Metformin-associated lactic acidosis is a well-described and commonly
encountered condition associated with significant morbidity and mortality. Patients with …

Introduction Metformin is a biguanide used to manage patients with type 2 diabetes mellitus.
However, metabolic acidosis with an elevated lactate concentration and death caused by …

Fibrates have been used for over forty-odd years to manage dyslipidemia and are generally
considered safe and well-tolerated.[1] However, little is known about the toxicity of fibrates in …

Rationale: The differential diagnosis for a patient with high-anion-gap metabolic acidosis
(HAGMA) is broad; lactic acidosis is an important entity to screen for and treat. An elevated …