[HTML][HTML] History and future perspectives on the discipline of quantitative systems pharmacology modeling and its applications
K Azer, CD Kaddi, JS Barrett, JPF Bai… - Frontiers in …, 2021 - frontiersin.org
Mathematical biology and pharmacology models have a long and rich history in the fields of
medicine and physiology, impacting our understanding of disease mechanisms and the …
medicine and physiology, impacting our understanding of disease mechanisms and the …
Stochastic simulation algorithms for computational systems biology: Exact, approximate, and hybrid methods
Nowadays, mathematical modeling is playing a key role in many different research fields. In
the context of system biology, mathematical models and their associated computer …
the context of system biology, mathematical models and their associated computer …
A QSP model of prostate cancer immunotherapy to identify effective combination therapies
Immunotherapy, by enhancing the endogenous anti-tumor immune responses, is showing
promising results for the treatment of numerous cancers refractory to conventional therapies …
promising results for the treatment of numerous cancers refractory to conventional therapies …
A quantitative systems pharmacology model of Gaucher disease type 1 provides mechanistic insight into the response to substrate reduction therapy with eliglustat
Gaucher's disease type 1 (GD1) leads to significant morbidity and mortality through clinical
manifestations, such as splenomegaly, hematological complications, and bone disease …
manifestations, such as splenomegaly, hematological complications, and bone disease …
Advancing precision medicine therapeutics for Parkinson's utilizing a shared quantitative systems pharmacology model and framework
C Denaro, D Stephenson, MLTM Müller… - Frontiers in Systems …, 2024 - frontiersin.org
A rich pipeline of therapeutic candidates is advancing for Parkinson's disease, many of
which are targeting the underlying pathophysiology of disease. Emerging evidence …
which are targeting the underlying pathophysiology of disease. Emerging evidence …
QSPcc reduces bottlenecks in computational model simulations
Mathematical models have grown in size and complexity becoming often computationally
intractable. In sensitivity analysis and optimization phases, critical for tuning, validation and …
intractable. In sensitivity analysis and optimization phases, critical for tuning, validation and …
[HTML][HTML] Reconstruction of the cytokine signaling in lysosomal storage diseases by literature mining and network analysis
Lysosomal storage diseases (LSDs) are characterized by the abnormal accumulation of
substrates in tissues due to the deficiency of lysosomal proteins. Among the numerous …
substrates in tissues due to the deficiency of lysosomal proteins. Among the numerous …
Mathematical modeling of prostate cancer immunotherapy
R Coletti - 2020 - iris.unitn.it
Immunotherapy, by enhancing the endogenous anti-tumor immune responses, is showing
promising results for the treatment of numerous cancers refractory to conventional therapies …
promising results for the treatment of numerous cancers refractory to conventional therapies …