Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms

A Inserra, D De Gregorio, G Gobbi, M Nader - Pharmacological Reviews, 2021 - Elsevier
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the …

RG Dos Santos, FL Osório, JAS Crippa… - Therapeutic …, 2016 - journals.sagepub.com
To date, pharmacological treatments for mood and anxiety disorders and for drug
dependence show limited efficacy, leaving a large number of patients suffering severe and …

Ayahuasca: psychological and physiologic effects, pharmacology and potential uses in addiction and mental illness

J Hamill, J Hallak, SM Dursun… - Current …, 2019 - ingentaconnect.com
Background: Ayahuasca, a traditional Amazonian decoction with psychoactive properties, is
made from bark of the Banisteriopsis caapi vine (containing beta-carboline alkaloids) and …

Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic …

AM Brito-da-Costa, D Dias-da-Silva, NGM Gomes… - Pharmaceuticals, 2020 - mdpi.com
Ayahuasca is a hallucinogenic botanical beverage originally used by indigenous
Amazonian tribes in religious ceremonies and therapeutic practices. While ethnobotanical …

Clinical and biological predictors of psychedelic response in the treatment of psychiatric and addictive disorders: A systematic review

B Romeo, M Hermand, A Pétillion, L Karila… - Journal of Psychiatric …, 2021 - Elsevier
Background The use of psychedelic treatments has shown very promising results in some
psychiatric and addictive disorders, but not all patients achieved a response. Aim The aim of …

The effects of psychedelics on neuronal physiology

CJ Hatzipantelis, DE Olson - Annual Review of Physiology, 2024 - annualreviews.org
Psychedelics are quite unique among drugs that impact the central nervous system, as a
single administration of a psychedelic can both rapidly alter subjective experience in …

Classical hallucinogens and neuroimaging: A systematic review of human studies: Hallucinogens and neuroimaging

RG Dos Santos, FL Osório, JAS Crippa… - … & Biobehavioral Reviews, 2016 - Elsevier
Serotonergic hallucinogens produce alterations of perceptions, mood, and cognition, and
have anxiolytic, antidepressant, and antiaddictive properties. These drugs act as agonists of …

Hypothesis: the psychedelic ayahuasca heals traumatic memories via a sigma 1 receptor-mediated epigenetic-mnemonic process

A Inserra - Frontiers in pharmacology, 2018 - frontiersin.org
Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and
epigenetic regulation. N, N-Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) …

Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO) inhibition: from ayahuasca to synthetic combinations of …

K Egger, HD Aicher, P Cumming… - Cellular and Molecular …, 2024 - Springer
The potent hallucinogen N, N-dimethyltryptamine (DMT) has garnered significant interest in
recent years due to its profound effects on consciousness and its therapeutic …

Effects of ayahuasca and its alkaloids on drug dependence: A systematic literature review of quantitative studies in animals and humans

AA Nunes, RG Dos Santos, FL Osório… - Journal of …, 2016 - Taylor & Francis
Recently, the anti-addictive potential of ayahuasca, a dimethyltryptamine (DMT)-and β-
carboline-rich hallucinogenic beverage traditionally used by indigenous groups of the …