Iron and copper have similar physiochemical properties; thus, physiologically relevant
interactions seem likely. Indeed, points of intersection between these two essential trace …

Iron metabolism and tumor biology are intimately linked. Iron facilitates the production of
oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute …

Several studies indicate that the cytosolic enzyme glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) has pleiotropic functions independent of its canonical role in …

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a glycolytic enzyme whose role in
cell metabolism and homeostasis is well defined, while its function in pathologic processes …

Streptococcus pneumoniae (Spn) alone and during co-infection with influenza A virus (IAV)
can result in severe pneumonia with mortality. Pneumococcal surface protein A (PspA) is an …

Protein secretion in eukaryotic cells is a well-studied process, which has been known for
decades and is dealt with by any standard cell biology textbook. However, over the past 20 …

Streptococcus pneumoniae (Spn), or the pneumococcus, is a Gram-positive bacterium that
colonizes the upper airway. Spn is an opportunistic pathogen capable of life-threatening …

Aside from its well-established role in glycolysis, glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) has been shown to possess many key functions in cells. These …

Streptococcus pneumoniae (Spn) resides in the nasopharynx, where it can disseminate to
cause disease. One key Spn virulence factor is pneumococcal surface protein A (PspA) …

Abstract Mycobacterium tuberculosis (M. tb), the major causative agent of tuberculosis, has
evolved mechanisms to evade host defenses and persist within host cells. Host-directed …