How development sculpts hippocampal circuits and function
R Cossart, R Khazipov - Physiological Reviews, 2022 - journals.physiology.org
In mammals, the selective transformation of transient experience into stored memory occurs
in the hippocampus, which develops representations of specific events in the context in …
in the hippocampus, which develops representations of specific events in the context in …
Parallel processing streams in the hippocampus
Highlights•Both granule cells and mossy cells contribute to DG pattern separation.•Studies
show functional dissociation along the CA3 transverse axis.•Similar to DG, proximal CA3 …
show functional dissociation along the CA3 transverse axis.•Similar to DG, proximal CA3 …
Neural population evidence of functional heterogeneity along the CA3 transverse axis: pattern completion versus pattern separation
Classical theories of associative memory model CA3 as a homogeneous attractor network
because of its strong recurrent circuitry. However, anatomical gradients suggest a functional …
because of its strong recurrent circuitry. However, anatomical gradients suggest a functional …
Proximodistal heterogeneity of hippocampal CA3 pyramidal neuron intrinsic properties, connectivity, and reactivation during memory recall
The hippocampal CA3 region is classically viewed as a homogeneous autoassociative
network critical for associative memory and pattern completion. However, recent evidence …
network critical for associative memory and pattern completion. However, recent evidence …
Topography of place maps along the CA3-to-CA2 axis of the hippocampus
L Lu, KM Igarashi, MP Witter, EI Moser, MB Moser - Neuron, 2015 - cell.com
We asked whether the structural heterogeneity of the hippocampal CA3-CA2 axis is
reflected in how space is mapped onto place cells in CA3-CA2. Place fields were smaller …
reflected in how space is mapped onto place cells in CA3-CA2. Place fields were smaller …
Hippocampal cholecystokinin-expressing interneurons regulate temporal coding and contextual learning
DKR Guerrero, K Balueva, U Barayeu, P Baracskay… - Neuron, 2024 - cell.com
Cholecystokinin-expressing interneurons (CCKIs) are hypothesized to shape pyramidal cell-
firing patterns and regulate network oscillations and related network state transitions. To …
firing patterns and regulate network oscillations and related network state transitions. To …
Sharpening the blades of the dentate gyrus: how adult‐born neurons differentially modulate diverse aspects of hippocampal learning and memory
G Berdugo‐Vega, S Dhingra, F Calegari - The EMBO Journal, 2023 - embopress.org
For decades, the mammalian hippocampus has been the focus of cellular, anatomical,
behavioral, and computational studies aimed at understanding the fundamental …
behavioral, and computational studies aimed at understanding the fundamental …
Dentate gyrus mossy cells share a role in pattern separation with dentate granule cells and proximal CA3 pyramidal cells
The complementary processes of pattern completion and pattern separation are thought to
be essential for successful memory storage and recall. The dentate gyrus (DG) and proximal …
be essential for successful memory storage and recall. The dentate gyrus (DG) and proximal …
Locus coeruleus phasic, but not tonic, activation initiates global remapping in a familiar environment
Locus coeruleus (LC) neurons, the source of hippocampal norepinephrine (NE), are
activated by novelty and changes in environmental contingencies. Based on the role of …
activated by novelty and changes in environmental contingencies. Based on the role of …
Pattern separation of spiketrains in hippocampal neurons
Pattern separation is a process that minimizes overlap between patterns of neuronal activity
representing similar experiences. Theoretical work suggests that the dentate gyrus (DG) …
representing similar experiences. Theoretical work suggests that the dentate gyrus (DG) …