The hidden Markov models are statistical models used in many real-world applications and
communities. The use of hidden Markov models has become predominant in the last …

Background. The evolution of primary glioblastoma (GBM) is poorly understood. Multifocal
GBM (ie, multiple synchronous lesions in one patient) could elucidate GBM development …

Radiation therapy is an important and effective treatment option for prostate cancer, but high-
risk patients are prone to relapse due to radioresistance of cancer cells. Molecular …

Background With the introduction of Olaparib treatment for BRCA-deficient recurrent ovarian
cancer, testing for somatic and/or germline mutations in BRCA1/2 genes in tumor tissues …

Background and objective: Affect provides contextual information about the emotional state
of a person as he/she communicates in both verbal and/or non-verbal forms. While human's …

Background Astrocytomas are the most common primary brain tumors distinguished into four
histological grades. Molecular analyses of individual astrocytoma grades have revealed …

In a real life process evolving over time, the relationship between its relevant variables may
change. Therefore, it is advantageous to have different inference models for each state of …

Melanoma is the most serious type of skin cancer that frequently spreads to other organs of
the human body. Especially melanoma metastases to the brain (intracranial metastases) are …

It has proven exceedingly difficult to ascertain rare copy number alterations (CNAs) that may
have strong effects in individual tumors. We show that a regulatory network inferred from …

Background The human microbiota plays a key role in health and disease, and bacteriocins,
which are small, bacterially produced, antimicrobial peptides, are likely to have an important …