Genome replication involves dealing with obstacles that can result from DNA damage but
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …

Accurate DNA replication and DNA repair are crucial for the maintenance of genome
stability, and it is generally accepted that failure of these processes is a major source of DNA …

We define the activity and mechanisms of action of a small molecule lead compound for
cancer targeting. We show that the compound, BMH-21, has wide and potent …

Ribosome biogenesis is a complex and energy-demanding process requiring tight
coordination of ribosomal RNA (rRNA) and ribosomal protein (RP) production. Given the …

DNA-RNA hybrids associated with R-loops promote DNA damage and genomic instability.
The capacity of hybrids at different genomic sites to cause DNA damage was not known, and …

Alterations in genome sequence and structure contribute to somatic disease, affect the
fitness of subsequent generations and drive evolutionary processes. The crucial roles of …

During transcription, the nascent RNA can invade the DNA template, forming extended RNA-
DNA duplexes (R-loops). Here we employ ChIP-seq in strains expressing or lacking RNase …

Abstract RNA Polymerase (Pol) I produces ribosomal (r) RNA, an essential component of the
cellular protein synthetic machinery that drives cell growth, underlying many fundamental …

Transcription has the capacity to mechanically modify DNA topology, DNA structure and
nucleosome arrangement. Resulting from ongoing transcription, these modifications in turn …

DNA and RNA polymerases clash along the genome as they compete for the same DNA
template. Cells have evolved specialized strategies to prevent and resolve replication and …