The effects of type 2 diabetes mellitus on organ metabolism and the immune system

G Daryabor, MR Atashzar, D Kabelitz, S Meri… - Frontiers in …, 2020 - frontiersin.org
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …

[HTML][HTML] Therapeutic host-directed strategies to improve outcome in tuberculosis

C Young, G Walzl, N Du Plessis - Mucosal immunology, 2020 - Elsevier
Abstract Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but
has limited efficacy against pulmonary TB disease development and modest protection …

Susceptibility for some infectious diseases in patients with diabetes: the key role of glycemia

J Chávez-Reyes, CE Escárcega-González… - Frontiers in public …, 2021 - frontiersin.org
Uncontrolled diabetes results in several metabolic alterations including hyperglycemia.
Indeed, several preclinical and clinical studies have suggested that this condition may …

Diabetes and tuberculosis

BI Restrepo - Understanding the host immune response against …, 2018 - Springer
The worldwide increase in the prevalence of diabetes has been most notable in TB-endemic
countries and has led to the re-emerging importance of the association between these two …

Immunometabolism during Mycobacterium tuberculosis infection

NC Howard, SA Khader - Trends in microbiology, 2020 - cell.com
Over a quarter of the world's population is infected with Mycobacterium tuberculosis (Mtb),
the causative agent of tuberculosis (TB). Approximately 3.4% of new and 18% of recurrent …

Diabetes-associated susceptibility to tuberculosis: contribution of hyperglycemia vs. Dyslipidemia

MD Ngo, S Bartlett, K Ronacher - Microorganisms, 2021 - mdpi.com
Diabetes is a major risk factor for tuberculosis (TB). Diabetes increases the risk of the
progression from latent tuberculosis infection (LTBI) to active pulmonary TB and TB patients …

Cellular immunity of patients with tuberculosis combined with diabetes

P Cheng, L Wang, W Gong - Journal of immunology research, 2022 - Wiley Online Library
Tuberculosis (TB) is one of humanity's three major infectious diseases. Diabetes mellitus
(DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin …

Changes in Host Response to Mycobacterium tuberculosis Infection Associated With Type 2 Diabetes: Beyond Hyperglycemia

CA Segura-Cerda, W López-Romero… - Frontiers in cellular …, 2019 - frontiersin.org
Tuberculosis (TB) remains as the first cause of death among infectious diseases worldwide.
Global incidence of tuberculosis is in part coincident with incidence of type 2 diabetes (T2D) …

Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility

P Ssekamatte, OJ Sande, R Van Crevel… - Frontiers in …, 2023 - frontiersin.org
Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between
DM and major global diseases like tuberculosis (TB) is of great public health significance …

Type 2 diabetes mellitus metabolic control correlates with the phenotype of human monocytes and monocyte-derived macrophages

MA Valtierra-Alvarado, JEC Delgado… - Journal of Diabetes and …, 2020 - Elsevier
Aims Monocytes and macrophages express cell-surface markers indicative of their
inflammatory and activation status. In this study, we investigated whether these markers are …