Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives

A Kumari, RK Singh - Bioorganic chemistry, 2019 - Elsevier
Indole is a versatile pharmacophore, a privileged scaffold and an outstanding heterocyclic
compound with wide ranges of pharmacological activities due to different mechanisms of …

Recent progress in biological activities of indole and indole alkaloids

TP Singh, OM Singh - Mini reviews in medicinal chemistry, 2018 - ingentaconnect.com
The indole scaffold is found in a wide range of bioactive heterocycles and natural products.
Moreover, the indole moiety is considered as the active principle in several alkaloids such …

Copper nanoparticles as inexpensive and efficient catalyst: A valuable contribution in organic synthesis

NK Ojha, GV Zyryanov, A Majee, VN Charushin… - Coordination Chemistry …, 2017 - Elsevier
Copper nanoparticles have been explored as a new class of heterogeneous catalyst in
various chemical transformations. This review surveys the most useful organic …

Antileishmanial drug discovery: Comprehensive review of the last 10 years

JN Sangshetti, FAK Khan, AA Kulkarni, R Arote… - Rsc Advances, 2015 - pubs.rsc.org
Leishmaniasis, a group of diseases caused by hemoflagellate obligate intracellular protozoa
(trypanosomatids) from the genus Leishmania, has not received the attention it deserves …

Leishmania treatment and prevention: Natural and synthesized drugs

AA Bekhit, E El-Agroudy, A Helmy, TM Ibrahim… - European journal of …, 2018 - Elsevier
Leishmaniasis affects over 150 million people all over the world, especially in subtropical
regions. Currently used antileishmanial synthesized drugs are associated with some …

Effective synthesis and biological evaluation of natural and designed bis (indolyl) methanes via taurine-catalyzed green approach

KA Chavan, M Shukla, ANS Chauhan, S Maji… - ACS …, 2022 - ACS Publications
An ecofriendly, inexpensive, and efficient route for synthesizing 3, 3′-bis (indolyl) methanes
(BIMs) and their derivatives was carried out by an electrophilic substitution reaction of indole …

Thiamine hydrochloride as a recyclable organocatalyst for the synthesis of bis (indolyl) methanes, tris (indolyl) methanes, 3, 3-di (indol-3-yl) indolin-2-ones and …

S Mathavan, K Kannan, RBRD Yamajala - Organic & Biomolecular …, 2019 - pubs.rsc.org
Thiamine hydrochloride was identified as an eco-friendly organocatalyst for the synthesis of
a broad range of bis (indolyl) methanes in good to excellent yields. Green chemistry matrix …

Synthesis of novel bisindolylmethane Schiff bases and their antibacterial activity

S Imran, M Taha, NH Ismail, KM Khan, F Naz… - Molecules, 2014 - mdpi.com
In an effort to develop new antibacterial drugs, some novel bisindolylmethane derivatives
containing Schiff base moieties were prepared and screened for their antibacterial activity …

CF3SO2Na-Mediated, UV-Light-Induced Friedel–Crafts Alkylation of Indoles with Ketones/Aldehydes and Bioactivities of Products

T Yang, H Lu, Y Shu, Y Ou, L Hong, CT Au, R Qiu - Organic letters, 2020 - ACS Publications
A concise, one-step route to produce 3, 3′-diindolylmethanes (DIMs) from simple indoles
and ketones or aldehydes is reported. The key step is the ready formation of indole …

NHPI-catalyzed electrochemical C–H alkylation of indoles with alcohols to access di (indolyl) methanes via radical coupling

B Li, H Qin, K Yan, J Ma, J Yang, J Wen - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
Di (indolyl) methanes are widely prevalent in pharmaceuticals, agrochemicals, alkaloids,
and natural products. Herein, we report a metal-free method for the uniform synthesis of …