The blood–brain barrier: structure, regulation, and drug delivery

D Wu, Q Chen, X Chen, F Han, Z Chen… - Signal Transduction and …, 2023 - nature.com
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Graphene quantum dots as a potential diagnostic and therapeutic tool for the management of Alzheimer's disease

S Ghosh, B Sachdeva, P Sachdeva, V Chaudhary… - Carbon Letters, 2022 - Springer
Alzheimer's disease (AD) is one of the most common forms of dementia, affecting more than
50 million people globally. The onset of AD is linked to age, smoking, obesity …

Nanoparticle-based drug delivery systems: an inspiring therapeutic strategy for neurodegenerative diseases

L Duan, X Li, R Ji, Z Hao, M Kong, X Wen, F Guan… - Polymers, 2023 - mdpi.com
Neurodegenerative diseases are common, incurable neurological disorders with high
prevalence, and lead to memory, movement, language, and intelligence impairments …

Nanomedicine: A Promising way to manage Alzheimer's disease

NH Khan, M Mir, EE Ngowi, U Zafar… - … in Bioengineering and …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a devastating disease of the aging population characterized by
the progressive and slow brain decay due to the formation of extracellular plaques in the …

Neuroprotective effect of phytoconstituents via nanotechnology for treatment of Alzheimer diseases

D Paramanick, VD Singh, VK Singh - Journal of Controlled Release, 2022 - Elsevier
Alzheimer's disease (AD) is a neurological condition characterised by cognitive and
behavioural dysfunction. The presence of the blood brain barrier (BBB), which prevents …

New drug delivery systems developed for brain targeting

SU Rawal, BM Patel, MM Patel - Drugs, 2022 - Springer
The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSF) are two of
the most complex and sophisticated concierges that defend the central nervous system …

Alzheimer's Disease Pathology and Assistive Nanotheranostic Approaches for Its Therapeutic Interventions

A Dey, S Ghosh, RL Rajendran… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Alzheimer's disease (AD) still prevails and continues to increase indiscriminately throughout
the 21st century, and is thus responsible for the depreciating quality of health and …

A tetrapeptide from maize combined with probiotics exerted strong anti-inflammatory effects and modulated gut microbiota in DSS-induced colitis mice

Z Li, S Zhang, L Xu, X Fang, Y Wan, D Yu, Y Guo - Food & Function, 2022 - pubs.rsc.org
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent
gastrointestinal inflammation caused by abnormal immune response, and patients usually …

Nanosystems for targeted drug Delivery: Innovations and challenges in overcoming the Blood-Brain barrier for neurodegenerative disease and cancer therapy

N Rafati, A Zarepour, A Bigham, A Khosravi… - International Journal of …, 2024 - Elsevier
The evolution of sophisticated nanosystems has revolutionized biomedicine, notably in
treating neurodegenerative diseases and cancer. These systems show potential in …

Protein and gene delivery systems for neurodegenerative disorders: where do we stand today?

PI Siafaka, ME Okur, PD Erim, EŞ Çağlar, E Özgenç… - Pharmaceutics, 2022 - mdpi.com
It has been estimated that every year, millions of people are affected by neurodegenerative
disorders, which complicate their lives and their caregivers' lives. To date, there has not …