The co-stimulatory and co-inhibitory immunoreceptors, DNAX accessory molecule-1 (DNAM-
1) and T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based …

Autoimmune diseases are characterized by dysfunctional immune systems that
misrecognize self as non‐self and cause tissue destruction. Several cell types have been …

CD8+ T cells within the tumor microenvironment (TME) are exposed to various signals that
ultimately determine functional outcomes. Here, we examined the role of the co-activating …

The activating receptor CD226 is expressed on lymphocytes, monocytes, and platelets and
promotes anti-tumor immunity in pre-clinical models. Here, we examined the role of CD226 …

CD226, a member of the immunoglobulin superfamily, is a functional protein initially
expressed on natural killer and T cells. In recent years, the function of CD226 has been …

Th1 Tregs are characterized by the acquisition of proinflammatory cytokine secretion and
reduced suppressor activity. Th1 Tregs are found at increased frequency in autoimmune …

Costimulation pathways play an essential role in T cell activation, differentiation, and
regulation. CD155 expressed on antigen-presenting cells (APCs) interacts with TIGIT, an …

To date, the overall response rate of PD-1 blockade remains unsatisfactory, partially due to
limited understanding of tumor immune microenvironment (TIME). B-cell lymphoma 9 …

The activation of T cells by the T cell antigen receptor (TCR) results in the formation of
signaling protein complexes (signalosomes), the composition of which has not been …

The conceptual basis for a genetic predisposition underlying the risk for developing type 1
diabetes (T1D) predates modern human molecular genetics. Over half of the genetic risk has …