Targeting transcription factors in cancer—from undruggable to reality
JH Bushweller - Nature Reviews Cancer, 2019 - nature.com
Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …
mediate aberrant gene expression, including blockade of differentiation and cell death gene …
The role of the transcription factor Ets1 in carcinoma
J Dittmer - Seminars in cancer biology, 2015 - Elsevier
Ets1 belongs to the large family of the ETS domain family of transcription factors and is
involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor …
involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor …
High-throughput data and modeling reveal insights into the mechanisms of cooperative DNA-binding by transcription factor proteins
Cooperative DNA-binding by transcription factor (TF) proteins is critical for eukaryotic gene
regulation. In the human genome, many regulatory regions contain TF-binding sites in close …
regulation. In the human genome, many regulatory regions contain TF-binding sites in close …
Identification of tRNA‐derived small RNA (tsRNA) responsive to the tumor suppressor, RUNX1, in breast cancer
Despite recent advances in targeted therapies, the molecular mechanisms driving breast
cancer initiation, progression, and metastasis are minimally understood. Growing evidence …
cancer initiation, progression, and metastasis are minimally understood. Growing evidence …
Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1
Transcriptional factors ETS1/2 and p52 synergize downstream of non-canonical NF-κB
signaling to drive reactivation of the− 146C> T mutant TERT promoter in multiple cancer …
signaling to drive reactivation of the− 146C> T mutant TERT promoter in multiple cancer …
Oncogenic ETS factors in prostate cancer
TR Nicholas, BG Strittmatter, PC Hollenhorst - Prostate Cancer: Cellular …, 2019 - Springer
Prostate cancer is unique among carcinomas in that a fusion gene created by a
chromosomal rearrangement is a common driver of the disease. The TMPRSS2/ERG …
chromosomal rearrangement is a common driver of the disease. The TMPRSS2/ERG …
Integrated phosphoproteome and transcriptome analysis reveals chlamydia-induced epithelial-to-mesenchymal transition in host cells
Chlamydia trachomatis (Ctr) causes a range of infectious diseases and is epidemiologically
associated with cervical and ovarian cancers. To obtain a panoramic view of Ctr-induced …
associated with cervical and ovarian cancers. To obtain a panoramic view of Ctr-induced …
ETS transcription factors: Multifaceted players from cancer progression to tumor immunity
Y Wang, Z Huang, M Sun, W Huang, L Xia - Biochimica et Biophysica Acta …, 2023 - Elsevier
The E26 transformation specific (ETS) family comprises 28 transcription factors, the majority
of which are involved in tumor initiation and development. Serving as a group of functionally …
of which are involved in tumor initiation and development. Serving as a group of functionally …
Ets family proteins regulate the EMT transcription factors Snail and ZEB in cancer cells
MK Ichikawa, K Endo, Y Itoh, AH Osada… - FEBS Open …, 2022 - Wiley Online Library
The epithelial–mesenchymal transition (EMT) is a crucial morphological event that occurs
during epithelial tumor progression. Snail and ZEB1/2 (ZEB1 and ZEB2), known as EMT …
during epithelial tumor progression. Snail and ZEB1/2 (ZEB1 and ZEB2), known as EMT …
Multiscale footprints reveal the organization of cis-regulatory elements
Cis-regulatory elements (CREs) control gene expression and are dynamic in their structure
and function, reflecting changes in the composition of diverse effector proteins over time …
and function, reflecting changes in the composition of diverse effector proteins over time …