The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

To date, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has determined 399,600,607 cases and 5,757,562 …

Synonymous mutations in protein-coding genes do not alter protein sequences and are thus
generally presumed to be neutral or nearly neutral,,,–. Here, to experimentally verify this …

The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

In less than one year since the outbreak of the COVID-19 pandemic, two mRNA-based
vaccines, BNT162b2 and mRNA-1273, were granted the first historic authorization for …

Abstract The Coronavirus disease-19 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), has impacted human lives in the most …

mRNA has broad potential as a therapeutic. Current clinical efforts are focused on
vaccination, protein replacement therapies, and treatment of genetic diseases. The clinical …

The world has been suffering from COVID-19 disease for more than a year, and it still has a
high mortality rate. In addition to the need to minimize transmission of the virus through non …

Abstract mRNA technologies have the potential to transform areas of medicine, including the
prophylaxis of infectious diseases. The advantages for vaccines range from the acceleration …