Restless legs syndrome (RLS), also known as Willis–Ekbom Disease (WED), is a
sensorimotor disorder for which the exact pathophysiology remains unclear. Brain iron …

The action of thyroid hormones (THs) in the brain is strictly regulated, since these hormones
play a crucial role in the development and physiological functioning of the central nervous …

Restless leg syndrome (RLS) is a sensorimotor disorder. Clinical studies have implicated
the dopaminergic system in RLS, while others have suggested that it is associated with …

Impaired sleep and alertness, initially recognized by James Parkinson in his famous
monograph “An Essay on the Shaking Palsy” in 1817, is one of the most common and …

The restless legs syndrome is a common disorder that encompasses an idiopathic form of
genetic or unknown origin and symptomatic forms associated with many causes …

Background and purpose: The evaluation of the pathophysiology of restless legs syndrome
(RLS) stems largely from recognition of the information provided by both pharmacological …

Clinical observations support a central role of the dopamine system in restless legs
syndrome (RLS) but previous imaging studies of striatal dopamine D2-receptors have …

Restless legs syndrome (RLS) is a common sensorimotor disorder for which two main
pathological elements are fairly well accepted: Brain iron deficiency (BID) and an altered …

Abstract Study Objectives: Rapid eye movement (REM) sleep behavior disorder (RBD) is
characterized by complex behavior during REM sleep. The etiology of this disorder is still …

The restless legs syndrome (RLS) is a neurologic condition characterized by an urge to
move, usually associated with paresthesia, that occurs or worsens at rest and is relieved by …