The development of oral squamous cell carcinoma (OSCC) is a multistep process requiring
the accumulation of multiple genetic alterations, influenced by a patient's genetic …

Despite commendable progress in the prevention, detection, and treatment of a wide variety
of solid tumor types, oral squamous cell carcinoma (OSCC) remains a significant health …

We have developed a self-assembled nanoparticle (NP) that efficiently delivers small
interfering RNA (siRNA) to the tumor by intravenous (IV) administration. The NP was …

Abstract Overexpression of cyclooxygenase 2 (COX2) and uncontrolled wingless and Int
(Wnt)-signaling pathway have long been suggested to play crucial roles in colorectal cancer …

Oral cancer is one of the major global threats to public health. Oral cancer development is a
tobacco‐related multistep and multifocal process involving field cancerization and …

Combination of two or more therapeutic strategies with different mechanisms can
cooperatively impede tumor growth. Co-delivery of chemotherapeutic drug and small …

We have developed a nanoparticle formulation [liposomes-protamine-hyaluronic acid
nanoparticle (LPH-NP)] for systemically delivering siRNA into the tumor. The LPH-NP was …

Abstract Background: Isotretinoin (13-cis-retinoic acid) is a synthetic vitamin A derivative, or
retinoid, widely used in the treatment of cystic acne. Preclinical and clinical studies of high …

Microbubble contrast agents can specifically deliver nucleic acids to target tissues when
exposed to ultrasound treatment parameters that mediate microbubble destruction. In this …

Oral cancer is one of the major global threats to public health. The development of oral
cancer is a tobacco‐related multistep and multifocal process involving field cancerization …