Increasing evidence suggests that migraine may be the result of an impaired brain glucose
metabolism. Several studies have reported brain mitochondrial dysfunction, impaired brain …

The implications of neurogenic inflammation and neuroinflammation in the pathophysiology
of migraine have been clearly demonstrated in preclinical migraine models involving several …

Calcitonin-gene-related peptide (CGRP) plays a key role in migraine pathophysiology and
more specifically in the mechanisms underlying peripheral and central sensitization. Here …

Migraine headaches are highly prevalent, affecting 15% of the population. However, despite
many studies to determine this disease's mechanism and efficient management, its …

Several lines of evidence support a role of the immune system in headache pathogenesis,
with particular regard to migraine. Firstly, alterations in cytokine profile and in lymphocyte …

Experimental findings suggest an involvement of neuroinflammatory mechanisms in the
pathophysiology of migraine. Specifically, preclinical models of migraine have emphasized …

In recent years, numerous efforts have been made to identify reliable biomarkers useful in
migraine diagnosis and progression or associated with the response to a specific treatment …

In several central nervous system diseases, it has been reported that inflammation may be
related to the etiologic process, therefore, therapeutic strategies are being implemented to …

Abstract Ethnopharmacological relevance Yufeng Ningxin Tablet (YNT) is a traditional
Chinese medicine formula, that has been used clinically to treat migraine for many years. It …

Background Chronic migraine places a disabling burden on patients, which is extensively
modeled by the nitroglycerin (NTG)-treated animal model. Although the NF-κB pathway is …