Ribonucleotide reductases (RNRs) transform RNA building blocks to DNA building blocks
by catalyzing the substitution of the 2′ OH-group of a ribonucleotide with a hydrogen by a …

Ribonucleotide reductases provide the building blocks for DNA replication in all living cells.
Three different classes of enzymes use protein free radicals to activate the substrate …

The p53 gene is frequently inactivated in human cancers. Here we have isolated a p53-
inducible gene, p53R2, by using differential display to examine messenger RNAs in a …

In Saccharomyces cerevisiae, MEC1 and RAD53 are essential for cell growth and
checkpoint function. Their essential role in growth can be bypassed by deletion of a novel …

Ribonucleotide reductase (RNR) is the enzyme responsible for the conversion of
ribonucleotides to 2′-deoxyribonucleotides and thereby provides the precursors needed …

In eukaryotes, DNA damage elicits a multifaceted response that includes cell cycle arrest,
transcriptional activation of DNA repair genes, and, in multicellular organisms, apoptosis …

Ribonucleotide reductase (RNR) is the only source for de novo production of the four
deoxyribonucleoside triphosphate (dNTP) building blocks needed for DNA synthesis and …

Ubiquitin is ligated to L28, a component of the large ribosomal subunit, to form the most
abundant ubiquitin–protein conjugate in S. cerevisiae. The human ortholog of L28 is also …

Ribonucleotide reductases (RNRs) catalyze all new production in nature of
deoxyribonucleotides for DNA synthesis by reducing the corresponding ribonucleotides. The …

Instability of the mitochondrial genome (mtDNA) is a general problem from yeasts to
humans. However, its genetic control is not well documented except in the yeast …