[HTML][HTML] Copper metabolism as a unique vulnerability in cancer
The last 25 years have witnessed tremendous progress in identifying and characterizing
proteins that regulate the uptake, intracellular trafficking and export of copper. Although …
proteins that regulate the uptake, intracellular trafficking and export of copper. Although …
Copper trafficking to the secretory pathway
S Lutsenko - Metallomics, 2016 - academic.oup.com
Copper (Cu) is indispensible for growth and development of human organisms. It is required
for such fundamental and ubiquitous processes as respiration and protection against …
for such fundamental and ubiquitous processes as respiration and protection against …
Structure of the Wilson disease copper transporter ATP7B
ATP7A and ATP7B, two homologous copper-transporting P1B-type ATPases, play crucial
roles in cellular copper homeostasis, and mutations cause Menkes and Wilson diseases …
roles in cellular copper homeostasis, and mutations cause Menkes and Wilson diseases …
[PDF][PDF] Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most
prevalent types of primary liver cancer. These malignancies have limited treatment options …
prevalent types of primary liver cancer. These malignancies have limited treatment options …
Dynamic and cell-specific transport networks for intracellular copper ions
S Lutsenko - Journal of cell science, 2021 - journals.biologists.com
Copper (Cu) homeostasis is essential for the development and function of many organisms.
In humans, Cu misbalance causes serious pathologies and has been observed in a growing …
In humans, Cu misbalance causes serious pathologies and has been observed in a growing …
[PDF][PDF] Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B−/− (Wilson disease) mice
JP Hamilton, L Koganti, A Muchenditsi… - …, 2016 - Wiley Online Library
Wilson disease (WD) is a hepatoneurological disorder caused by mutations in the copper‐
transporter, ATP7B. Copper accumulation in the liver is a hallmark of WD. Current therapy is …
transporter, ATP7B. Copper accumulation in the liver is a hallmark of WD. Current therapy is …
Analysis of Wilson disease mutations revealed that interactions between different ATP7B mutants modify their properties
Wilson disease (WD) is an autosomal-recessive disorder caused by mutations in the copper
(Cu)-transporter ATP7B. Thus far, studies of WD mutations have been limited to analysis of …
(Cu)-transporter ATP7B. Thus far, studies of WD mutations have been limited to analysis of …
Acclimation to Nutritional Immunity and Metal Intoxication Requires Zinc, Manganese, and Copper Homeostasis in the Pathogenic Neisseriae
AH Branch, JL Stoudenmire, KL Seib… - Frontiers in Cellular …, 2022 - frontiersin.org
Neisseria gonorrhoeae and Neisseria meningitidis are human-specific pathogens in the
Neisseriaceae family that can cause devastating diseases. Although both species inhabit …
Neisseriaceae family that can cause devastating diseases. Although both species inhabit …
Direct interaction of ATP7B and LC3B proteins suggests a cooperative role of copper transportation and autophagy
S Pantoom, A Pomorski, K Huth, C Hund, J Petters… - Cells, 2021 - mdpi.com
Macroautophagy/autophagy plays an important role in cellular copper clearance. The
means by which the copper metabolism and autophagy pathways interact mechanistically is …
means by which the copper metabolism and autophagy pathways interact mechanistically is …
Human copper transporter ATP7B (Wilson disease protein) forms stable dimers in vitro and in cells
ATP7B is a copper-transporting P 1B-type ATPase (Cu-ATPase) with an essential role in
human physiology. Mutations in ATP7B cause the potentially fatal Wilson disease, and …
human physiology. Mutations in ATP7B cause the potentially fatal Wilson disease, and …