Sarcomas are a rare group of mesenchymal cancers comprising over 70 different
histological subtypes. For the majority of these diseases, the molecular understanding of the …

Background Small cell lung cancer (SCLC) is a deadly, high grade neuroendocrine (NE)
tumor without recognized morphologic heterogeneity. However, over 30 years ago we …

Members of the small GTP ase family Rab are emerging as potentially important factors in
cancer development and progression. A good number of Rabs have been implicated or …

As the most aggressive tumor, the outcome of pancreatic cancer (PACA) has not improved
observably over the last decade. Anatomy-based TNM staging does not exactly identify …

Aberrant activation of EGFR in human cancers promotes tumorigenesis through stimulation
of AKT signaling. Here, we determined that the discoidina neuropilin-like membrane protein …

Background Epigenetics refers to the reversible functional modifications of the genome that
do not correlate to changes in the DNA sequence. The aim of this study is to understand …

Background: DCBLD2 is highly expressed in various cancers, including colorectal cancer.
DCBLD2 overexpression promotes tumor occurrence, development, and metastasis …

Background Aberrant methylation is a known cause of cancer initiation and/or progression.
There are scant data on the genome‐wide methylation pattern of nonfunctioning pancreatic …

Transforming growth factor (TGF)-β signaling is deliberately regulated at multiple steps in its
pathway from the extracellular microenvironment to the nucleus. However, how TGF-β …

Abstract Background Circular RNAs (circRNAs) have recently been found to be expressed in
human brain tissue, and many lines ofevidence indicate that circRNAs play regulatory roles …