Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders
Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …
Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders
In a research environment dominated by reductionist approaches to brain disease
mechanisms, gene network analysis provides a complementary framework in which to tackle …
mechanisms, gene network analysis provides a complementary framework in which to tackle …
Gene co-expression analysis for functional classification and gene–disease predictions
S Van Dam, U Vosa, A van der Graaf… - Briefings in …, 2018 - academic.oup.com
Gene co-expression networks can be used to associate genes of unknown function with
biological processes, to prioritize candidate disease genes or to discern transcriptional …
biological processes, to prioritize candidate disease genes or to discern transcriptional …
Sex-specific transcriptional signatures in human depression
Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the
incidence, symptoms and treatment of MDD all point toward major sex differences, the …
incidence, symptoms and treatment of MDD all point toward major sex differences, the …
Cell type-specific transcriptomics reveals that mutant huntingtin leads to mitochondrial RNA release and neuronal innate immune activation
The mechanisms by which mutant huntingtin (mHTT) leads to neuronal cell death in
Huntington's disease (HD) are not fully understood. To gain new molecular insights, we …
Huntington's disease (HD) are not fully understood. To gain new molecular insights, we …
A multidimensional systems biology analysis of cellular senescence in aging and disease
Background Cellular senescence, a permanent state of replicative arrest in otherwise
proliferating cells, is a hallmark of aging and has been linked to aging-related diseases …
proliferating cells, is a hallmark of aging and has been linked to aging-related diseases …
DNA methylation age of human tissues and cell types
S Horvath - Genome biology, 2013 - Springer
Background It is not yet known whether DNA methylation levels can be used to accurately
predict age across a broad spectrum of human tissues and cell types, nor whether the …
predict age across a broad spectrum of human tissues and cell types, nor whether the …
Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
Introduction Microglia are tissue macrophages of the central nervous system that monitor
brain homeostasis and react upon neuronal damage and stress. Aging and …
brain homeostasis and react upon neuronal damage and stress. Aging and …
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …
Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice
P Langfelder, JP Cantle, D Chatzopoulou… - Nature …, 2016 - nature.com
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's
disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue …
disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue …